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. 2006 Nov 6;149(8):1092–1103. doi: 10.1038/sj.bjp.0706945

Table 3.

Potential therapeutic targets of ginsenoside Rg1 identified from INVDOCK search of human and mammalian proteins

PDB ID Target name Experimental findings Therapeutic implications
1rpa DNA polymerase β Rg1 stimulates DNA synthesis. Rg1 activates DNA polymerase delta (Cho et al., 1995; Lee and Lee, 1996). Cancer (Shin et al., 2000)
1rmh Cyclophilin A   Immune response (Kenarova et al., 1990)
3nos Endothelial nitric-oxide synthase (NOS) Rg1 inhibits NOS dose dependently (Li et al., 1997). Maintaining optimal oxidative status (Kitts and Hu, 2000)