Table 3.
Potential therapeutic targets of ginsenoside Rg1 identified from INVDOCK search of human and mammalian proteins
| PDB ID | Target name | Experimental findings | Therapeutic implications |
|---|---|---|---|
| 1rpa | DNA polymerase β | Rg1 stimulates DNA synthesis. Rg1 activates DNA polymerase delta (Cho et al., 1995; Lee and Lee, 1996). | Cancer (Shin et al., 2000) |
| 1rmh | Cyclophilin A | Immune response (Kenarova et al., 1990) | |
| 3nos | Endothelial nitric-oxide synthase (NOS) | Rg1 inhibits NOS dose dependently (Li et al., 1997). | Maintaining optimal oxidative status (Kitts and Hu, 2000) |