Figure 1.

Schematic illustration of the experimental protocols. (a) Represents the protocol in which the drugs were added in a sequential mode (administration for 10 min followed by 10 min drug-free perfusion). (b) Shows the experimental protocol of the single dose experiments in which drugs were infused for 10 min followed by 40 min with drug-free buffer. (c) Represents the protocol use for addition of the inhibitors of the signalling pathways where the inhibitors were administered before infusion of CORM-3.