Table 3.
Competition for radioligand binding to HEK 293(EBNA) cell membranes expressing recombinant prostanoid receptors
| Ligands | EP1 | EP2 | EP3 | EP4 |
|---|---|---|---|---|
| PGE2 | 9.1 | 4.9 | 0.33 | 0.79 |
| Butaprost | 27 721 | 91 | 1643 | 19 104 |
| AH-6809 | 1217 | 1150 | 1597 | 100 000 |
| Sulprostone | 107 | 100 000 | 0.35 | 7740 |
| M&B-28767 | 419 | 988 | 0.14 | 10 |
| Iloprost | 11 | 1870 | 56 | 284 |
| Misoprostol | 11 935 | 34 | 7.9 | 23 |
| PGD2 | 5820 | 2973 | 421 | 1483 |
| PGF2α | 547 | 964 | 38 | 288 |
| SC-51322 | 13.8 | >100 000 | 698 | 14 032 |
| Enprostil | 82 | >10 000 | 12 | >10 000 |
| Carbacyclin | 23 | 942 | 14 | 352 |
| Cicaprost | >1340 | >1340 | 255 | 44 |
Abbreviations: EP, E prostanoid; PGD2, prostaglandin D2; PGE2, prostaglandin; PGF2α, prostaglandin F2α.
Inhibitory constant (Ki) values are expressed in nM.
Adapted from Abramovitz et al. (2000).