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Effect of rhAPC inhalation on coagulant and inflammatory mediators during acute pulmonary inflammation. (a) TATc levels in BALF as a marker for the activation of coagulation. TNFα (b) and IL-6 (c) levels in BALF represent the production of pro-inflammatory mediators. Mediators were measured 6 h after LPS administration and for baseline levels (no LPS administration) of mice treated with vehicle (saline) or 100 μg rhAPC. Data shown are mean±s.e.; *P<0.05 vs vehicle.
