Table 1.

Effect of increased treatment with rhAPC on LPS-induced TNFα, IL-6 and TATc levels in BALF

	(A) rhAPC inhalation		(B) Increased rhAPC inhalation
	Saline	100 μg APC	Saline	100 μg APC
TNFα (pg/ml)	733.8±84.44	440.0±71.91*	797.9±67.14	448.8±33.79***
IL-6 (pg/ml)	954.2±92.31	604.1±125.0*	1088±167.2	587.2±152.3*
TATc (ng/ml)	9.55±2.20	4.39±1.19*	8.40±0.76	5.15±0.75*

(A) 100 μg rhAPC administered 30 min before and 3 h after LPS exposure compared to saline treatment also represented in Figure 1. (B) 100 μg rhAPC administered 30 min before and 1, 3 and 5 h after LPS exposure compared to saline treatment. Data shown are mean±s.e.

^*P<0.05

^***P<0.0001 vs saline treatment.