Figure 3.

Effect of TDZD-8 on carrageenan-induced P-selectin expression and PMN infiltration in the lung. No positive staining for P-selectin was observed in lung sections taken from sham mice treated with TDZD-8 (10 mg kg⁻¹ a). Lung sections taken from carrageenan-treated mice pre-treated with vehicle showed intense positive staining for P-selectin along the vessels (b). The degree of positive staining for P-selectin was markedly reduced in tissue sections obtained from mice pre-treated with 10 mg kg⁻¹ TDZD-8 (c). MPO activity, index of PMN infiltration, was significantly elevated at 4 h after carrageenan (CAR) administration in vehicle-treated mice (d). TDZD-8 (1, 3 and 10 mg kg⁻¹ i.p.) significantly reduced MPO activity in the lung in a dose-dependent fashion (d). The figure is representative of at least three experiments performed on different experimental days. Data are expressed as mean±s.e.m. from n=10 mice for each group. ^*P<0.01 versus sham group. °P<0.01 versus carrageenan.