Figure 2.

Effect of J-113863 on collagen-induced arthritis. DBA-1 mice with established disease received either vehicle (V) or the test drug for 11 days by i.p. route. (a) Effect of J-113863 at 3 mg kg⁻¹ (J-3) and 10 mg kg⁻¹ (J-10) on the clinical manifestations of the disease (arthritic index). (b) Effect of the compound on anti-collagen II antibodies of the IgG1 and IgG2A subtypes, measured at the end of the experiment. Results shown are representative of three independent experiments using seven mice per treatment group. ^*P<0.05; ^**P<0.01 vs vehicle, Student's t-test.