Figure 3.

Effect of the CCR1 antagonist on paw histology. Microscopic images (× 10 for (a, c); 20 × for (b)) representative of the paw of arthritic mice treated with vehicle or 10 mg kg⁻¹ of J-113863 illustrating the joint space (asterisks), the invasive pannus (arrowheads), and the presence of osteoclasts (arrows). (d) Inhibition of the joint damage score by J-113863 at 3 and 10 mg kg⁻¹ vs vehicle. Results shown are representative of three independent experiments using seven mice per treatment group. ^*P<0.05 vs vehicle-treated mice, Student's t-test.