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Involvement of the HPA axis in the effect of J-113863 on TNFα and IL-10. Adrenalectomized or sham-operated mice received vehicle (V) or 10 mg kg−1 of J-113863 (J) or rolipram (also 10 mg kg−1; R) followed, half an hour later, by an LPS challenge. Results shown are representative of two independent experiments using five animals per group. *P<0.05, **P<0.01 vs corresponding vehicle-treated mice, Student's t-test.
