Figure 3.

Effects of nicotine and 5-hydroxyindole (5-OHi), alone or in combination, on the release of endogenous glutamate from mouse cortical synaptosomes. 5-Hydroxyindole was added 8 min before nicotine. Data are mean ±s.e.mean of 5–9 experiments run in triplicate. ^*P<0.05; ^**P<0.01 versus nicotine (two-tailed student's t-test). Inset: effect of nicotine and 5-hydroxyindole alone or in combination on glutamate overflow (total minus basal release). ^*P<0.05; ^**P<0.01 versus nicotine (two-tailed student's t-test).