Figure 1.

The RANTES/CCL5 signalling cascade mediated via the novel chemokine receptor, GPR75. Inhibition of observed signalling by the use of wortmannin and U73122 is also shown. Although the involvement of PKC in this pathway has not been directly demonstrated, activation of PKC has been previously reported to enhance the survival of the HT22 murine hippocampal cell line (Maher, 2001). Note the large third intracellular loop linking transmembrane helices V and VI and also the long C-terminus extending from transmembrane helix VII. These regions of GPR75 are anticipated to interact with the heterotrimeric G protein and may account for the atypical signalling described by Ignatov et al. (2006).