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. 2006 Oct 3;149(5):542–550. doi: 10.1038/sj.bjp.0706893

Figure 2.

Figure 2

Effects of both ZD0947 and glibenclamide on the CCh-induced contraction of human detrusor strips. The dashed line indicates the zero tone level. (a) CCh (300 nM, 4 min application) caused a contraction. In the presence of 10 μM ZD0947, the CCh-induced contraction was suppressed. After treatment with 1 μM glibenclamide, the CCh-induced contraction recovered to the control level, even in the presence of ZD0947. The results illustrated were obtained from a single smooth muscle strip. (b) Relative amplitude of the CCh-induced contraction under the indicated conditions. The amplitude of the CCh-induced contraction was normalized as 1.0 (Control, open column). The solid column indicates the relative amplitude of 10 μM ZD0947-induced relaxation. The hatched column represents the relative amplitude of the CCh-induced contraction in the presence of ZD0947. Asterisks indicate a statistically significant difference, demonstrated using a paired t-test (P<0.01). Each column represents the relative mean value with +s.d. (n=4).