Figure 6.
Ru360 treatment diminishes the initial mitochondrial calcium uptake rate. (a) Time course analysis of mitochondrial calcium uptake. In mitochondria from control, I/R and I/R+Ru360 (50 nmol kg−1) rat hearts. The insert shows the statistical analysis of initial calcium influx rate (nmol Ca2+ mg−1). *P⩽0.05 significantly different vs control and †P⩽0.05 vs I/R. (b) CSA inhibits the mPTP in mitochondria from I/R hearts. Calcium transport was measured in isolated heart mitochondria from I/R rats in the presence of 1 μM CSA and without CSA. The data represent the mean of at least five different hearts (a) and four experiments (b)±s.e.