Table 2.
Effects of chronic treatment with atorvastatin, fluvastatin and fenofibrate on biochemical parameters in rat plasma
| Treatment | ||||||
|---|---|---|---|---|---|---|
| Plasma parameter | Control | Atorvastatin 10 mg kg−1 | Fluvastatin 5 mg kg−1 | Fluvastatin 20 mg kg−1 | Fenofibrate 60 mg kg−1 | ANOVA |
| Myoglobin | 0.14±0.02 | 0.23±0.01 | 0.16±0.02 | 0.28±0.05 | 0.23±0.03 | F=4.27 |
| (ng ml−1) | *P<0.02 | *P<0.005 | *P<0.025 | §P<0.01 | ||
| LDH | 587±76 | 1255±202 | 550±77 | 915±151 | 1065±295 | F=4.08 |
| (mU ml−1) | *P<0.005 | *P<0.025 | §P<0.01 | |||
| CK | 1238±217 | 2118±202 | 1468±40 | 1795±189 | 1517±437 | F=2.31 |
| (mU ml−1) | *P<0.005 | *P<0.05 | NS | |||
| Creatinine | 7±0.3 | 8±0.5 | 7±0.8 | 8±0.6 | 7±0.7 | F=0.06 |
| (μg ml−1) | NS | |||||
| Potassium | 5.9±0.3 | 6.8±0.7 | 5.5±0.6 | 5.3±0.6 | 6.6±0.4 | F=1.45 |
| (mEq l−1) | NS | |||||
| Azotemia | 0.48±0.02 | 0.55±0.04 | 0.45±0.03 | 0.62±0.05 | 0.54±0.01 | F=3.8 |
| (mg ml−1) | *P<0.005 | §P<0.02 | ||||
| N (samples) | 10 | 6 | 7 | 7 | 5 | |
Abbreviations: ANOVA, analysis of variance; CK, creatine kinase; LDH, lactate dehydrogenase.
Each row shows the mean±s.e.m. of the plasma parameters measured from the number of samples as indicated.
§
Significantly different by ANOVA test
*
Significantly different with respect to control (by Bonferroni's t-test).