Table 4.
Effects of atorvastatin, fluvastatin and fenofibrate treatments on membrane excitability of rat extensor digitorum longus muscle fibres
| Treatment | N rats/n fibres | AP (mV) | Ith (nA) | Lat (ms) | N spikes |
|---|---|---|---|---|---|
| Control | 10/51 | 101±1.3 | 188±7.1 | 5.6±0.2 | 4.0±0.3 |
| Atorvastatin (10 mg kg−1) | 9/34 | 99±2.5 | 205±9.0 | 6.7±0.5 | 5.4±0.5 |
| *P<0.02 | *P<0.02 | ||||
| Fluvastatin (5 mg kg−1) | 8/23 | 106±2.1 | 175±9.1 | 8.3±0.4 | 6.3±0.5 |
| *P<0.05 | *P<0.001 | *P<0.001 | |||
| Fluvastatin (20 mg kg−1) | 7/21 | 107±2.9 | 130±7 | 10.3±0.5 | 7.0±0.7 |
| *P<0.025 | *P<0.001 | *P<0.001 | *P<0.001 | ||
| Fenofibrate (60 mg kg−1) | 9/38 | 100±1.7 | 193±10 | 6.5±0.4 | 5.5±0.6 |
| *P<0.05 | *P<0.01 | ||||
| F=2.57 | F=7.86 | F=19.4 | F=5.16 | ||
| ANOVA | §P<0.05 | §P<0.001 | §P<0.001 | §P<0.001 |
Abbreviation: ANOVA, analysis of variance.
The columns from left to right indicate as follows: N rats/n fibres, number of rats examined on number of fibres sampled; AP, amplitude of the first action potential (peak); Ith, threshold current (minimum current intensity that would elicit a single action potential); Lat, latency of the first action potential (maximal delay from the beginning of the current pulse to the onset of the spike); N spikes, maximum number of action potentials elicited by raising the intensity of a 100 ms-duration pulse in the same fibre. As detailed in the Methods section AP and Lat were calculated from traces obtained using Ith current. The values are mean±s.e.m.
Significantly different by ANOVA test
Significantly different with respect to control (by Bonferroni's t-test).