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. 2006 Oct 16;149(7):861–869. doi: 10.1038/sj.bjp.0706935

Figure 3.

Figure 3

Binding of the radioligand [11C]MDL 100907 in rat brain determined by (a) PET and (b) ex vivo methods. Rats received [11C]MDL 100907 alone (open columns, n=5), 5 min after SB 242084 1 mg kg−1 i.v. (filled columns, n=4), or 5 min after non-radioactive MDL 100907 (0.2–0.4 mg kg−1 i.v.) (striped columns, n=4). Brain regions: a, olfactory bulbs; b, hypothamus; c, striatum; d, frontal with cingulate cortex; e, hippocampus, f, superior colliculi; g, medulla. Data are mean±s.d. values. Note that SB 242084 did not affect [11C]MDL 100907 binding in any region whereas unlabelled MDL 100907 reduced [11C]MDL 100907 binding to unity (P<0.05: Student's t-test).