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. 2006 Oct 23;149(7):870–879. doi: 10.1038/sj.bjp.0706895

Figure 2.

Figure 2

Effects of diazoxide, cromakalim and AM10 on IKATP in single native mouse pancreatic β cell. (a) Average amplitude of IKATP in the presence of 10 mM glucose and diazoxide (Dz) or cromakalim (Cromak), at the indicated concentrations. (b) Time course of IKATP amplitude. The glucose concentration was 10 mM throughout the experiment (Glc 10). AM10 (100 nM) and diazoxide (Dz, 200 μM) were added when indicated. Each square represents the amplitude of IKATP elicited by a 100-ms duration pulse of ±20 mV from the holding potential of −70 mV. (c) Average amplitude of IKATP in the presence of 10 mM glucose and AM10 alone or with diazoxide, at the indicated concentrations. Panel (a) and (c) represent the mean of 3–8 experiments and panel (b) is a trace representative of three experiments. *P<0.05; **P<0.01.