Table 4.
The Relationship of Risk Alleles and Haplotype of STAT4 with High CCP and RF Titer
| Haplotype | |||
|---|---|---|---|
| TTCG | Others | P value | |
| High antiCCPa | 0.50 | 0.48 | 0.46 |
| High RFa | 0.42 | 0.39 | 0.33 |
| RF titerb | |||
| Mean | 219.9 | 181.9 | 0.29 |
| Median | 79.4 | 73.5 | |
| 25 percentile | 36.2 | 36.2 | |
| 75 percentile | 215.0 | 183.5 | |
a
We divided the cases into high or low anti-CCP/RF group based on the titer ≥ 100 units; Values indicate the frequency of cases with high anti-CCP or high RF out of given subjects; All risk alleles (data not shown) and haplotype do not affect the high anti-CCP or high RF titer frequency using chi square test [ORs (95% CI) 1.09 (0.86–1.38) and 1.11 (0.90–1.38) in order].
b
RF titer was not significantly related to risk haplotype using nonparametric statistics despite a trend toward higher titer in the risk groups.