Table 2.

Extended E-D model of breast cancer and prostate cancer

Hormone receptor	Property
Membrane androgen receptor	↑apoptotic proteins ↓bcl-2 (BC only) ↑bcl-2 (PC only) ↓AS3 ↑Ca++ influx
Intracellular androgen receptor	↓apoptotic proteins ↓bcl-2 ↑AS3 ↓Ca++ influx ↑calreticulin
Estrogen receptor-αβ heterodimer	↑telomerase activity (PC only)
Estrogen receptor-α homodimer	↑telomerase activity
Estrogen receptor-α	↑bcl-2
Estrogen receptor-β	↓bcl-2
Membrane estrogen receptor	↑bcl-2
Progesterone receptor A	↑bcl-2
Progesterone receptor B	↓bcl-2
Membrane progesterone receptor	↓bcl-2