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. 2007 Sep 6;4:84. doi: 10.1186/1743-422X-4-84

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Copyright © 2007 Prepens et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Alignment of LNA-substituted oligonucleotides. The LNAs, used in this study for specific inhibition of LCV amplification, were multiply aligned with their target sequences. The LNA-substituted bases are highlighted by circles. Identical nucleotides are boxed. For comparison, an LCV consensus sequence is shown, which was derived from all published LCV DPOL sequences. The bases 1 and 175 are the first and the last base of the sequence, which is amplified from LCV with pan-herpes DPOL primers (Bases 154668 and 154494 of the EBV B 95–8 genome [Acc. V01555], respectively). Only the 5'- and the 3'-ends are shown, the central part of the consensus sequence is represented by the dotted line. The 3'- ends of the binding regions of the inner consensus primers TGV (sense) and IYG (antisense) are indicated.