Table 1.
Candidate H. bacteriophora genes for RNAi gene silencing
| GeneA | Predicted FunctionB | C. e. Ortholog | %Identity, lengthC | C. elegans PhenotypesD [ref] |
| Hba-cct-2 | T-complex chaperonin | T21B10.1 (Cel-cct-2) | 79, 357 | Emb, Ste [13,14], Pch, Pvl, [14], Lva [13] |
| Hba-daf-21 | Hsp-90 chaperonin | C47E8.5 (Cel-daf-21) | 79, 804 | Emb, Ste [31] |
| Hba-icd-1 | BTF3 transcription factor Anti-apoptotic | C56C10.8 (Cel-icd-1) | 75, 529 | Emb [13,14, 31], Gro [13,14,15], Stp [14,15], Bmd, Clr, Sck [13], Unc [14] |
| Hba-nol-5 | Ribosome biogenesis Nop58p/Nop5p | W01B11.3 (Cel-nol-5) | 74, 634 | Lva [14,31,53], Emb, Lva [31,53], Gro, Muv, Pvl, Sle, Stp, [31] |
| Hba-W01G7.3 | RNA polymerase subunit L | W01G7.3 (Cel-W01G7.3) | 80, 81 | Emb [13,14,15,31], Gro [14,31], Ste, Stp [31], Pvl [14], Lva [15] |
| Hba-rack-1 | G protein β-like subunit | K04D7.1 (Cel-rack-1) | 75, 441 | Gro [13,14], Emb, Egl [13], Slu [14] |
| Hba-arf-1 | ADP-ribosylating factor | B0336.2 (Cel-arf-1) | 75, 219 | Emb [13,14,36], Unc [13,14], Pvl, Rup, Ste [13], Gro [14] |
| Hba-ben-1 | β-tubulin, benomyl sensitivity | C54C6.2 (Cel-ben-1) | 78, 518 | no phenotype reported |
| Hba-mrp-4 | Mrp-1 multidrug resistance family | F21G4.2 (Cel-mrp-4) | 61, 468 | no phenotype reported |
| Hba-nhr-47 | nuclear hormone receptor | C24G66.4 (Cel-nhr-47) | 65, 269 | no phenotype reported |
A Based on ESTs, see methods for accession #'s.
B Based on Wormbase gene description for C. elegans ortholog.
C Based on BLASTN analysis in Wormbase.
D RNAi phenotypes reported previously. Abbreviations are: Bmd = body morphology defect, Clr = clear, Egl = egg laying defective, Emb = embryonic lethal, Gro = slow growth, Muv = multivulva, Pch = patchy coloration, Pvl = protruded vulva, Sck = sick, Sle = slow embryonic development, Slu = sluggish, Ste = sterile, Stp = sterile progeny, Unc = uncoordinated