Table 2.

Secondary parameters to be included in WARN Pharmacokinetic Database, if available.

Patient characteristics	Antimalarial	Methodology	Pharmacokinetic parameters
Height	Directly Observed Therapy (DOT) [1]	Method for separating free drug	Primary parameters: Absorption rate constant (Ka); Elimination Rate constant (Ke), Volume of distribution; Clearance rate.
Vomiting	Batch number & Expiry Date	Sample handling	Secondary parameters: Cmax, tmax, elimination half-life;
Diarrhoea	Method of Administration [2]		Total vs free drug
Baseline parasite density	Co-administration [3]		Metabolites
Haematocrit, Bilirubin, Creatinine, Albumin (alpha1 glycoprotein, lipoprotein)
Ethnicity

Footnotes to Table 2

DOT: All doses supervised; First dose supervised; Unsupervised.

2. Administration: Whole tablets; Divided tablets; Crushed tablets.

3. Co-administration: Water; Fat content; Sugar water; Concomitant medication