Table 3.
Crude† and adjusted‡ coefficients (95% CI) for a change in thyroid hormone level§ associated with an interquartile range increase in serum PCB, DDE, or HCB#. N=341.
| Analyte# | Crude† | Adjusted‡ | ||||
|---|---|---|---|---|---|---|
| Free T4†† | Total T3†† | TSH‡‡ | Free T4†† | Total T3†† | TSH‡‡ | |
| PCB118 | -0.015 (-0.057, 0.028) | -0.010 (-0.040, 0.022) | 0.98 (0.89, 1.09) | -0.010 (-0.055, 0.035) | -0.002 (-0.034, 0.026) | 0.93 (0.84, 1.04) |
| PCB138 | -0.010 (-0.047, 0.027) | -0.036 (-0.054, -0.001)** | 0.94 (0.86, 1.03) | 0.015 (-0.025, 0.054) | -0.018 (-0.046, 0.011) | 0.92 (0.84, 1.01)* |
| PCB153 | -0.007 (-0.043, 0.030) | -0.036 (-0.062, -0.009)** | 0.93 (0.86, 1.02) | 0.027 (-0.014, 0.067) | -0.024 (-0.053, 0.005)* | 0.92 (0.84, 1.01)* |
| ΣPCB | -0.017 (-0.055, 0.021) | -0.036 (-0.063, -0.008)** | 0.94 (0.86, 1.03) | 0.017 (-0.025, 0.060) | -0.022 (-0.053, 0.008) | 0.93 (0.84, 1.03) |
| Group1 | -0.009 (-0.041, 0.024) | -0.025 (-0.049, -0.001)** | 0.94 (0.87, 1.02) | 0.018 (-0.017, 0.056) | -0.015 (-0.041, 0.011) | 0.94 (0.86, 1.02) |
| Group2 | -0.018 (-0.058, 0.022) | -0.032 (-0.060, -0.002)** | 0.95 (0.87, 1.05) | 0.008 (-0.035, 0.051) | -0.022 (-0.053, 0.009) | 0.93 (0.84, 1.03) |
| Group3 | -0.014 (-0.052, 0.023) | -0.038 (-0.065, -0.011)** | 0.95 (0.87, 1.03) | 0.025 (-0.018, 0.068) | -0.024 (-0.055, 0.007) | 0.95 (0.85, 1.05) |
| p,p-DDE | 0.017 (-0.014, 0.048) | 0.022 (0.000, 0.044)* | 0.93 (0.87, 1.00)* | 0.036 (0.005, 0.068)** | 0.033 (0.011, 0.056)** | 0.92 (0.86, 1.00)** |
| HCB | 0.011 (-0.027, 0.049) | -0.015 (-0.043, 0.012) | 0.95 (0.87, 1.04) | 0.021 (-0.018, 0.060) | -0.018 (-0.046, 0.010) | 0.95 (0.87, 1.04) |
p<0.1
p<0.05
†Adjusted for serum lipids (%) as a covariate.
‡Adjusted for serum lipids (%), age, BMI, current smoking, and time of blood draw (morning vs. afternoon).
§Log-transformation of TSH concentration was used. Free T4 and Total T3 concentrations were modeled untransformed.
In all models ln-transformations of serum concentrations of organochlorine pesticides / PCBs were used.
Coefficient represents the change in hormone level for an IQR change in pesticide/PCB concentration after back-transformation of the pesticide/PCB concentrations. For an IQR change in pesticide/PCB concentration, a coefficient equal to 0 indicates no change in hormone level, a coefficient < 0 indicates a decrease in hormone level, and a coefficient > 0 indicates an increase in hormone level.
Coefficient represents a multiplicative change in hormone level for an IQR change in pesticide/PCB concentration after back-transformation of both hormone and pesticide/PCB concentrations. For an IQR change in pesticide/PCB concentration, a coefficient equal to 1.0 indicates no change in hormone level, a coefficient < 1.0 indicates a multiplicative decrease in hormone level, and a coefficient > 1.0 indicates a multiplicative increase in hormone level.