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. 1997 Mar 18;94(6):2676–2680. doi: 10.1073/pnas.94.6.2676

Figure 2.

Figure 2

PDTC differentially regulates NFκB expression in Jurkat cells and glial cultures as determined by electrophoretic mobility shift assays. (A) In Jurkat cells, TNF-α (300 units per ml) enhances NFκB activity, which peaks at 30 min. PDTC (100 μM) inhibits TNF-α-induced NFκB activation at all time points. Representative blots are shown for experiments that were performed at least three independent times with similar results. (B) TNF-α (300 units per ml) induces NFκB activation in cultured glia. PDTC (100 μM) fails to inhibit TNF-α (300 units per ml)-induced NFκB activation. Note the higher levels of P50 dimer in glia compared with Jurkat cells.