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Averaged CAR middle latency changes over time after intravenous injection of 0.15 mg kg−1 midazolam (▪), α-hydroxy-midazolam (□), or placebo (○). Data are expressed as means of six healthy volunteers. The benzodiazepine time-effect curves were significantly different from the placebo curves (midazolam: P < 0.003, α-hydroxy-midazolam: P < 0.008; anova for repeated measures).
