Table 2.
i.v. | s.c.b. | s.c.i. | |
---|---|---|---|
Appearance t½ (h) | 0.18 ± 0.02 | 0.28 ± 0.09 * | 1.21 ± 0.61 **# |
Elimination t½ (h) | 3.6 ± 1.1 | 4.1 ± 1.3 | 3.5 ± 1.8 |
Cmax (nmol l−1) | 66.7 ± 14.8 | 62.2 ± 17.5 | 30.1 ± 1.9**## |
tmax (h) | 0.63 (0.5-0.75) | 1.25 (0.25-1.5) | 5.25 (5.0-6.0)***### |
AUC(0,t) (nmol l−1 h) | 259 ± 60 | 252 ± 42 | 171 ± 15*# |
AUC(0,∞) (nmol l−1 h) | 291 ± 66 | 290 ± 59 | 171 ± 15*# |
Bioavailability (%) | 100 | 102.0 ± 17.4 | 74.5 ± 22.2*# |
M6G:M AUC(0,∞) | 1.33 ± 0.25 | 1.19 ± 0.25 | 1.28 ± 0.48*# |
See legend to Table 1 for details.