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. 2000 Mar;49(3):207–214. doi: 10.1046/j.1365-2125.2000.00141.x

Table 2.

Pharmacokinetic parameters for M6G after i.v., s.c.b. and s.c.i. administration of morphine to healthy volunteers.

i.v. s.c.b. s.c.i.
Appearance t½ (h) 0.18 ± 0.02 0.28 ± 0.09 * 1.21 ± 0.61 **#
Elimination t½ (h) 3.6 ± 1.1 4.1 ± 1.3 3.5 ± 1.8
Cmax (nmol l−1) 66.7 ± 14.8 62.2 ± 17.5 30.1 ± 1.9**##
tmax (h) 0.63 (0.5-0.75) 1.25 (0.25-1.5) 5.25 (5.0-6.0)***###
AUC(0,t) (nmol l−1 h) 259 ± 60 252 ± 42 171 ± 15*#
AUC(0,∞) (nmol l−1 h) 291 ± 66 290 ± 59 171 ± 15*#
Bioavailability (%) 100 102.0 ± 17.4 74.5 ± 22.2*#
M6G:M AUC(0,∞) 1.33 ± 0.25 1.19 ± 0.25 1.28 ± 0.48*#

See legend to Table 1 for details.