Table 3.

Pharmacokinetic parameters for M3G after i.v., s.c.b and s.c.i administration of morphine to healthy volunteers.

	i.v.	s.c.b	s.c.i
Appearance t½ (h)	0.07 ± 0.04	0.44 ± 0.67*	0.92 ± 0.54*
Elimination t½ (h)	3.1 ± 0.7	2.8 ± 0.5	3.3 ± 1.4
Cmax (nmol l−1)	334 ± 75	280 ± 65	135 ± 47**
tmax (h)	0.25 (0.17-0.75)	1.0 (0.5-2.0)*	5.25 (2.5-6.0)*
AUC(0,t) (nmol l−1 h)	1022 ± 256	1085 ± 308	645 ± 329
AUC(0,∞) (nmol l−1 h)	1293 ± 288	1308 ± 345	848 ± 208*
Bioavailability (%)	100	104.1 ± 32.5	69.5 ± 26.0
M3G:M AUC(0,∞)	5.9 ± 0.2	5.4 ± 1.3	5.0 ± 1.6
M3G:M6G AUC(0,∞)	4.5 ± 0.9	4.5 ± 0.4	4.1 ± 0.9

See legend to Table 1 for details.