Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism-based inactivation of CYP2D6 by desethylamiodarone. The recombinant CYP2D6 was preincubated with 0 μm (○), 0.5 μm (•), 1 μm (□), and 2 μm (▪) desethylamiodarone for 0, 5, 10, 15, and 20 min at 37 °C in the presence of an NADPH-generating system. After preincubation, bufuralol was added to the reaction mixture and BFOH was determined.
