Table 4.

Identification of individual drug entities included within drug groups in Dutch HDFs (n = 62). The musculoskeletal and central nervous system.

	HDFs				HDFs
Drug group (ATC code)	Year*	n	(%)	Drug group(ATC code)	Year*	n	(%)
NSAIDs(M01A/N02BB/N02BG)				Benzodiazepines(N05BA/N05 CD) None		1	(2)
Acetic acid derivates				Alprazolam ***	1983	0	(0)
Aceclofenac	1997	0	(0)	Bromazepam	1974	0	(0)
Diclofenac **	1974	60	(97)	Brotizolam	1982	2	(3)
Indomethacin	1963	56	(90)	Chlorodiazepoxide ***	1960	0	(0)
Sulindac	1976	11	(18)	Clobazam ***	1975	0	(0)
Tolmetine	1975	2	(3)	Clorazepinic acid ***	1967	0	(0)
				Diazepam **/+	1961	23	(37)
Oxicam derivates				Flunitrazepam ***	1974	11	(18)
Meloxicam	1996	1	(2)	Flurazepam ***	1968	19	(31)
Piroxicam	1979	27	(44)	Ketazolam	1980	0	(0)
Tenoxicam ***	1986	0	(0)	Loprazolam	1983	0	(0)
				Loprazolam	1971	17	(28)
Proprionic acid derivates				Lormetazepam	1980	25	(40)
Fenoprofen	1974	0	(0)	Medazepam ***	1968	27	(44)
Flurbiprofen	1977	0	(0)	Midazolam	1982	0	(0)
Ibuprofen **/+	1969	59	(95)	Nitrazepam **	1965	47	(76)
Ketoprofen	1973	19	(31)	Nordazepam ***	1975	0	(0)
Naproxen **	1973	57	(92)	Oxazepam	1964	19	(31)
Tiaprofenic acid	1980	0	(0)	Prazepam ***	1973	0	(0)
				Temazepam **	1969	61	(98)
Pyrazolinon derivates				Triazolam	1978	0	(0)
Aminophenazone	1887	0	(0)	Zolpidem	1988	4	(7)
Phenazone	1884	0	(0)	Zopiclon	1985	12	(19)
Metamizol ***	1946	3	(5)
Propyphenazone	1951	0	(0)
Other
Azapropazone	1970	9	(14)
Floctafenine	1976	0	(0)
Ketorolac	1990	0	(0)
Phenylbutazone	1949	13	(21)
Nabumeton	1985	7	(11)
Proquazone	1977	0	(0)
Tolphenaminic acid	1975	0	(0)

^*Year of introduction to the pharmaceutical market

^**Recommended by national guidelines

^***Not preferred or insufficiently evaluated by guideline authorities; Drug entities without asterisks are not considered in the national pharmacotherapeutic guidelines

⁺Included in the 10th edition of the WHO EDL.