Table 1.
Characteristics of pregnant women having obtained a prescription for metoclopramide at the pharmacy and women without exposureto any reimbursed, prescribed medications and outcome of birth.
| Variable | Exposure only in interval 11 | Exposure only in interval 22 | Exposure at any time in interval 1 or 23 | References not exposed4 |
|---|---|---|---|---|
| Number of pregnancies | 190 | 295 | 309 | 13327 |
| Number of prescriptions | 239 | 428 | 443 | - |
| Maternal mean age, years | 27.9 | 27.5 | 27.5 | 27.8 |
| Range, years | 18–41 | 17–41 | 17–41 | 13–47 |
| Smokers, % | 19.4 | 24.1 | 24.6 | 28.9 |
| Birth order, no. 1 | 79 | 130 | 136 | 7472 |
| Birth order, > no. 1 | 111 | 165 | 173 | 5855 |
| Gestational age (weeks) | ||||
| ≥ 37 weeks | 176 | 278 | 292 | 12534 |
| 34–36 weeks | 9 | 10 | 10 | 540 |
| < 34 weeks | 5 | 7 | 7 | 253 |
| Mean birth weight, g | 3489 | 3480 | 3483 | 3470 |
| Range, g | 883–5530 | 883–5530 | 883–5530 | 500–5520 |
| Number of malformations | 11 | 15 | 16 | 697 |
| Number of low birth weight | 11 | 18/7** | 18 | 657/209** |
| Number of preterm deliveries | 14 | 17 | 17 | 793 |
| Number of stillborn (before birth) | 0 | 1 | 1 | 31 |
| Number of stillborn (during birth) | 1 | 1 | 1 | 15 |
**
restricted to full-term deliveries.
1
Exposed to metoclopramide 30 days before conception to end of 1st trimester.
2
Exposed to metoclopramide in 2nd or 3rd trimester.
3
Exposed to metoclopramide at any time from 30 days before conception to delivery.
4
Reference pregnancies not exposed to any prescribed, reimbursed drugs at any time during pregnancy.