Table 2.
Risk of adverse pregnancy outcomes according to exposure to metoclopramide and maternal characteristics.
| Malformations | Outcome Low birth weight | Preterm delivery | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Crude analysis | 95% CI | Adjusted | 95% CI | Crude analysis | 95% CI | Adjusted | 95% CI | Crude analysis | 95% CI | Adjusted | 95% CI |
| No exposures to metoclopramide | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Exposure to metoclopramide | 1.18 | 0.64–2.19 | 1.11 | 0.60–2.06 | 1.52 | 0.71–3.28 | 1.79 | 0.83–3.86 | 0.97 | 0.59–1.59 | 1.02 | 0.62–1.67 |
| Birth order, number | ||||||||||||
| 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| >1 | 0.84 | 0.71–1.0 | 0.85 | 0.73–0.99 | 0.62 | 0.47–0.82 | 0.55 | 0.40–0.75 | 0.82 | 0.71–0.95 | 0.77 | 0.66–0.90 |
| Non-smoking | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Smoking | 1.17 | 1.0–1.38 | 1.18 | 1.0–1.38 | 3.68 | 2.80–4.84 | 3.7 | 2.81–4.87 | 1.27 | 1.09–1.48 | 1.28 | 1.10–1.49 |
| Maternal age, years | ||||||||||||
| <25 years | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| 25–30 years | 0.86 | 0.71–1.04 | 0.82 | 0.68–0.99 | 0.6 | 0.43–0.82 | 0.79 | 0.57–1.09 | 0.85 | 0.71–1.01 | 0.92 | 0.77–1.10 |
| >30 year | 1 | 0.8–1.25 | 0.9 | 0.73–1.11 | 0.79 | 0.56–1.12 | 1.19 | 0.81–1.75 | 1 | 0.82–1.21 | 1.16 | 0.94–1.44 |