Table 4.
Baseline serum glucose and insulin concentrations and postprandial responses in Caucasian and Aboriginal subjects given a standard breakfast after gliclazide administration. Data are mean ± s.d. or geometric mean [s.d. range].
| Caucasian | Aboriginal | 95% CI on difference | |
|---|---|---|---|
| Baseline serum glucose (mmol l−1) | 12.1 ± 3.9 | 10.9 ± 3.8 | 2.5, −4.9 |
| Baseline serum insulin (mU l−1) | 20.3[8.4–49.0] | 14.5 [6.9–30.3] | 10, −32¶ |
| HOMA-derived beta cell function (%) | 50 [18–137] | 46 [21–100] | 36, −64¶ |
| HOMA-derived insulin sensitivity (%) | 15[7–36] | 22[10–46] | 25, −8¶ |
| Glucose incremental area under the curve (AUCglucose; mmol l−1 h) | 2.0 ± 6.0 | 9.5 ± 11.2 | 16.3, −1.3 |
| Insulin incremental area under the curve (AUCinsulin; mU l−1 h) | 84 ± 111 | 157 ± 130 | 190, −43 |
| Maximum glucose concentration (Cmax, glucose; mmoll−1h) | 15.8 ± 5.2 | 16.1 ± 4.9 | 5.2, −4.6 |
| Maximum insulin concentration (Cmax, insulin; mUl−1h) | 73.4 [40.2–133.9] | 65.0 [31.3–134.9] | 50.7, −58.4¶ |
| Time to maximum glucose concentration (tmax, glucose; h) | 2.2 ± 0.3 | 2.6 ± 0.4* | 0.78, 0.06 |
| Time to maximum insulin concentration (tmax, insulin; h) | 2.4 ± 0.5 | 2.1 ± 0.6 | 0.3, −0.3 |
¶
derived from untransformed data
*
P = 0.024 vs Caucasian group.