Table 1.
Pharmacokinetic parameters of bambuterol.
| Data after dose 1 | Data during treatment | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Treatment | n | Mean | Min | Max | Dose 8 | Dose 15 | n | Mean | Min | Max |
| Cmax (nmol l−1) | T10 | 20 | 3.69 | 1.0 | 8.8 | 23 | 4.35 | 1.7 | 11.1 | ||
| T20 | 23 | 8.56 | 3.5 | 16.9 | X | X | 23 | 10.11 | 3.8 | 21.4 | |
| T20 | – | – | – | – | X | 24 | 10.30 | 2.6 | 30.2 | ||
| S20 | 24 | 6.13 | 1.7 | 13.6 | X | 25 | 7.51 | 2.5 | 14.9 | ||
| T30 | 22 | 14.23 | 5.3 | 30.4 | X | 23 | 16.75 | 7.4 | 46.1 | ||
| AUC1 (nmol l−1 h) | T10 | 15 | 37.3 | 16 | 62 | X | 19 | 20.1 | 5 | 39 | |
| T20 | 22 | 66.8 | 34 | 161 | X | 24 | 60.3 | 19 | 136 | ||
| T20 | – | – | – | – | X | 24 | 55.3 | 15 | 143 | ||
| S20 | 21 | 55.5 | 23 | 93 | X | 25 | 56.6 | 12 | 112 | ||
| T30 | 20 | 108.6 | 42 | 160 | X | 23 | 123.7 | 42 | 376 | ||
| MRT (h) | T10 | 15 | 21.1 | 8 | 34 | X | 19 | 8.0 | 2 | 29 | |
| T20 | 22 | 19.2 | 8 | 34 | X | 22 | 16.4 | 3 | 56 | ||
| T20 | – | – | – | – | X | 24 | 14.4 | 3 | 28 | ||
| S20 | 21 | 19.2 | 8 | 29 | X | 24 | 14.8 | 2 | 34 | ||
| T30 | 20 | 18.3 | 6 | 31 | X | 22 | 15.2 | 4 | 31 | ||
| t½,z (h) | T10 | 6 | 20.14 | 15.2 | 26.7 | X | 10 | 20.90 | 10.5 | 50.7 | |
| T20 | 12 | 18.47 | 8.6 | 32.8 | X | 18 | 16.52 | 7.3 | 40.7 | ||
| S20 | 15 | 18.82 | 6.6 | 27.4 | X | 19 | 13.31 | 6.8 | 20.1 | ||
| T30 | 16 | 16.85 | 7.0 | 32.6 | X | 20 | 15.04 | 7.0 | 33.8 | ||
1
AUC(0,∞) after dose 1 and AUC(0,24 h) after doses 8 and 15. X shows the dosing interval from which data are given during repeated treatment.