Table 1.
Effect of activated charcoal (25 g) and gastric lavage on the absorption of temazepam, verapamil and moclobemide. Gastric decontamination was performed 5 min after ingestion of the drugs.
| AUC (0,24 h) | Cmax | tmax | Excretion in urine over 24 h | ||||
|---|---|---|---|---|---|---|---|
| (ng ml−1h) | (% of control) | (ng ml−1) | (% of control) | (h) | (µg) | (% of control) | |
| Temazepam 10 mg | |||||||
| + water (control) | 2280 ± 1030 | 100 | 421 ± 120 | 100 | 0.5 (0.5–1) | 21 ± 14 | 100 |
| + activated charcoal | 108 ± 117**‡ | 4.8 | 21.9 ± 35.2**‡ | 5.2 | 1 (0.5–3) | 6.0 ± 6.2*† | 28.6 |
| + gastric lavage | 1690 ± 1290 | 74.4 | 241 ± 157** | 57.3 | 0.5 (0.5–1.5) | 18 ± 15 | 85.7 |
| Verapamil 80 mg | |||||||
| + water (control) | 223 ± 118 | 100 | 38.6 ± 20.9 | 100 | 1.5 (0.5–2) | 518 ± 311 | 100 |
| + activated charcoal | 16.2 ± 13.4**‡ | 7.2 | 2.3 ± 2.6**‡ | 5.9 | 1.5 (1–3) | 30 ± 48**‡ | 5.8 |
| + gastric lavage | 214 ± 107 | 96 | 35.6 ± 17.7 | 92.3 | 1.5 (0.5–3) | 487 ± 395 | 94.0 |
| Moclobemide 150 mg | |||||||
| + water (control) | 5050 ± 3230 | 100 | 1110 ± 417 | 100 | 1 (0.5–2) | 1300 ± 822 | 100 |
| + activated charcoal | 13.5 ± 19.2**† | 0.3 | 5.9 ± 8.2**‡ | 0.5 | 1 (0–2) | 2.3 ± 3.2*‡ | 0.2 |
| + gastric lavage | 3420 ± 2550 | 67.7 | 725 ± 370 | 65.4 | 1.5 (0.5–3) | 954 ± 1240 | 73.3 |
Data are mean values ± s.d. for nine subjects; tmax is given as median with range
*
Significantly (P < 0.05) different from control
**
Significantly (P < 0.01) different from control
†
Significantly (P < 0.05) different from gastric lavage
‡
Significantly (P < 0.01) different from gastric lavage.