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. 2000 Apr;49(4):353–362. doi: 10.1046/1365-2125.2000.00145.x

Table 7.

Examples of complications which resolved on re-institution of preadmission medicines.

Diagnosis/age Drug withdrawn Symptoms Consequences Resolution
Breast cancer with secondary deposits
63 years Nitrazepam Psychotic, confused, drowsy ? cerebral mets, CT scan, lumbar puncture, power of attornery withdrawn permanently, lawyers involved, family rifts Diazepam started once nitrazepam withdrawal recognized as cause of symptoms, lucid within 12 h.
Abdominal aortic aneurysm repair
75 years Sinemet Movements difficult during this time Mobilization delayed and chest complications Symptoms resolved once Sinemet re-introduced day 9 postop.
Aorto-bi-iliac graft
85 years Doxepin Tearful, anxious and depressed Mobilization delayed Doxepin reintroduced 23 days later and patient much improved
Caecopexy
66 years Sinemet Movements difficult during this time Mobilization delayed and chest complications Symptoms resolved once Sinemet re-introduced.
Aorto-bi-iliac graft
63 years Sotalol, lisinopril Day 1 postop pulmonary oedema and systolic BP > 200 mmHg despite adequate pain control and other causes eliminated, day 6 started sips, and hypertensive again Needed prn nifedipine sl to control hypertension Admission meds re-instated day 6 and became normotensive.
Left hemicolectomy/anterior resection
67 years Captopril, pindolol, bumetanide Day 2 systolic BP > 200 mmHg despite adequate pain control and other causes eliminated. Also BP became quite labile. Day 7 bp 175/90 mmHg Intravenous metoprolol given until day 5 and nifedipine sl until day 8 Captopril restarted day 8, became normotensive
Abdominoperineal resection
69 years Viskaldix Steady rise in BP. Day 4190/100 mmHg + headache Still ‘nbm’ but Visaldix recommenced Normotensive day 4 and fluids introduced day 6.
Transverse colectomy
64 years Cyclopenthiazide, diltiazem
Day 3 BP 200/130 mmHg Pain from concurrent osteoarthritis Mobilization a problem because of NSAID withheld Needed 3 dose of nipedipine to become normotensive Restarted on diltiazem and became normotensive
Abdominoperineal resection
67 years Enalapril, nadolol Hypertensive, 190/120 mmHg (Day 1) 200/116 mmHg (Day 2) 230/120 mmHg (Day 3) Needed prn nifedipine sl to control hypertension Admission meds re-instated day 3 and became normotensive.
Anterior resection
65 years Enalapril Day 3 hypertensive 190/110 mmHg Re-started admission meds Admission meds re-instated day 3 and became normotensive