Table 1.

Pharmacokinetic data of amiodarone (mean ± s.d.).

	Period 1 (water)	Period 2 (grapefruit juice)	95% CI on mean difference	P
Cmax (µg ml−1)	1.87 ± 0.6	3.45 ± 1.7	0.67, 2.42	< 0.02
tmax (h)	4.08 ± 1.66	3.63 ± 0.96	−1.79, 0.89	NS
AUC (µg ml−1 h)	23.9 ± 11.2	35.9 ± 14.3	6.14, 17.84	< 0.005
t½ (h)	11.56 ± 8.0	9.53 ± 5.5	−5.21, −1.18	NS