Table 2.

ECG alterations during period 1 (water) and period 2 (grapefruit juice) at 6 h postdose (mean ± s.d.).

	Period 1			Period 2
	Baseline	Amiodarone and water	% of increase	Baseline	Amiodarone and grapefruit	% of increase
PR (ms)	166.2 ± 14.2	196.3 ± 23.7	17.9 P < 0.001	168.2 ± 14.8	186.1 ± 28.8	10.2 P < 0.01
RR (s)	0.89 ± 0.17	0.895 ± 0.12	2.86 NS	0.876 ± 0.15	0.930 ± 0.10	8.70 NS
QTc	0.38 ± 0.03	0.42 ± 0.03	11.28 P < 0.001	0.39 ± 0.03	0.40 ± 0.02	3.33 NS