Table 1.
Mean (%CV) pharmacokinetic information for the four groups.
| Controls | Child-Pugh A | Child-Pugh B | Child-Pugh C | |
|---|---|---|---|---|
| n | 6 | 5 | 7 | 5 |
| Cmax (ng ml−1) | 643 (37) | 886 (43) | 1048 (26) | 1273 (33) |
| Ratio; CIb,c | 135%; 86–213 | 167%; 110–253 | 198%; 126–311 | |
| tmax (h) | 1.33 (39) | 1.60 (56) | 1.29 (38) | 1.60 (34) |
| AUC(0,72 h) (ng ml−1 h) | 10927 (29) | 11284 (54) | 12274 (25) | 14454 (57) |
| AUC(tf) (ng ml−1 h) | 15162 (40) | 13046 (74) | 14184 (38) | 18392 (75) |
| Ratio; CIb,c | 76%; 37–158 | 94%; 48–185 | 101%; 49–210 | |
| Ae(0,72 h) (mg) | 53.6 a (15) | 56.0 (44) | 57.3 (41) | 53.3 (33) |
| % Dose | 9 a (15) | 9 (44) | 10 (41) | 9 (33) |
| CLr (l h−1) | 5.35a (29) | 5.27 (34) | 4.73 (42) | 5.21 (68) |
| Ratio; CIb | 98%; 41–156 | 88%; 35–141 | 97%; 50–155 |
a
n = 5;
b
ratio = mean differences as percentage of control; 95% confidence intervals for ratio;
c
ratio and confidence interval based on log-transformed data.