Table 1.

Plasma AUC(0,12 h) data on days 7 and 21 of twice daily oral dosing of 200 mg NaVPA.

AUC(0,12 h)	Day 7	Day 21	Mean difference	95% CI
VPA (µmol ml−1 h)	2.84 ± 0.79	2.40 ± 0.54	0.438	0.128–0.811 *
E-2-en-VPA (µmol ml−1 h)	0.149 ± 0.042	0.147 ± 0.040	0.002	−0.018–0.022
3-oxo-VPA (µmol h ml−1)	0.491 ± 0.056	0.468 ± 0.076	0.023	−0.025–0.072
E-2-en-VPA/VPA	0.0534 ± 0.0149	0.0630 ± 0.0179	−0.0096	−0.146 to −0.0046 *
3-oxo-VPA/E-2-en-VPA	3.54 ± 1.11	3.32 ± 0.91	0.217	−0.544–0.979

AUC, area under the plasma concentration-time curve over a steady state interdosing interval from 08.00–20.00 h; mean ± s.d., n = 12.

^*95% CI excludes zero.