Table 2.

% recovery of the 200 mg NaVPA dose in urine as various metabolites.

Recovery	Day 7	Day 21	Mean difference	95% CI
VPA-glucuronide (%)	9.38 ± 3.75	7.55 ± 3.59	1.83	−0.53–4.18
E-2-en-VPA (%)	0.167 ± 0.166	0.310 ± 0.192	−0.143	−0.309–0.023
3-oxo-VPA (%)	42.7 ± 11.3	49.6 ± 13.9	−6.92	−17.3–3.43
4-OH-VPA (%)	2.00 ± 1.00	1.61 ± 1.21	0.40	−0.34–1.14
Total recovery (%)	54.2 ± 14.5	59.1 ± 17.0	−4.84	−17.6–7.89

Urinary recovery over a steady state interdosing interval from 08.00 to 20.00 h, mean± s.d., n = 12. E-2-en-VPA, 3-oxo-VPA and 4-OH-VPA are measured as the sum of nonconjugated and conjugated species.