. 2000 May;49(5):409–415. doi: 10.1046/j.1365-2125.2000.00191.x

Table 3.

Plasma clearance (CL/F) of VPA and formation clearances to various urinary metabolites.

Clearance	Day 7	Day 21	Mean difference	95% CI
Plasma VPA (ml kg⁻¹ h⁻¹)	6.17 ± 1.50	7.30 ± 2.33	−1.13	−2.20 to −0.636 ^*
VPA-glucuronide (ml kg⁻¹ h⁻¹)	0.534 ± 0.145	0.505 ± 0.182	0.029	−0.062–0.121
E-2-en-VPA (ml kg⁻¹ h⁻¹)	0.010 ± 0.009	0.024 ± 0.016	−0.014	−0.025 to −0.004 ^*
3-oxo-VPA (ml kg⁻¹ h⁻¹)	2.57 ± 0.75	3.60 ± 1.47	−1.03	−1.72 to −0.339 ^*
4-OH-VPA (ml kg⁻¹ h⁻¹)	0.112 ± 0.046	0.110 ± 0.074	0.0021	−0.038–0.042
Unaccounted for (ml kg⁻¹ h⁻¹)	2.96 ± 1.50	3.07 ± 1.81	−0.108	−1.25–1.03

Clearances over a steady state interdosing interval from 08.00 to 20.00 h, mean ± s.d., n = 12.

95% CI excludes zero.