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Nonspecific binding parameters for nortriptyline and amitriptyline at varying microsome concentrations.
| Microsomal protein (mg ml−1) | Bmax (µm) | KD1 (µm) |
|---|---|---|
| Nortriptyline | ||
| 0.5 | 220 ± 32 | 151 ± 42 |
| 1.0 | 382 ± 54 | 147 ± 44 |
| 2.0 | 707 ± 54 | 111 ± 3 |
| Amitriptyline | ||
| 1.0 | 375 ± 23 | 178 ± 33 |
Values are mean ± s.d. of three determinations.
