Table 5.

Risk factors for upper gastrointestinal events and iron deficiency anaemia during the study.

		Number of events	Rate (Number of events per 1000 patient- months of exposure)	Rate ratio (95% CI)	P value
Past history of gastrointestinal disorder*
Dyspepsia	No past history	341	7.6	1
	Past history	464	22.5	3.0 (2.6, 3.4)	< 0.0001
Abdominal pain	No past history	166	3.7	1
	Past history	156	7.6	2.1 (1.6, 2.6)	< 0.0001
Upper GI haemorrhage	No past history	21	0.5	1
	Past history	10	0.5	1.0 (0.4, 2.3)	0.5
Iron deficiency anaemia	No past history	11	0.2	1
	Past history	7	0.3	1.4 (0.5, 3.9)	0.2
Peptic ulcer	No past history	6	0.1	1
	Past history	11	0.5	4.0 (1.4, 13.2)	0.003
Past history of NSAID use†
Dyspepsia	No past history	434	14.9	1
	Past history	386	10.3	0.7 (0.6, 0.8)	< 0.0001
Abdominal pain	No past history	157	5.4	1
	Past history	166	4.4	0.8 (0.7, 1.0)	0.04
Upper GI haemorrhage	No past history	12	0.4	1
	Past history	19	0.5	1.2 (0.6, 2.8)	0.3
Iron deficiency anaemia	No past history	5	0.2	1
	Past history	14	0.4	2.2 (0.7, 7.7)	0.07
Peptic ulcer	No past history	6	0.2	1
	Past history	10	0.3	1.3 (0.4, 4.3)	0.3
Concurrent gastroprotective agent‡
Dyspepsia	No past history	427	8.5	1
	Past history	393	25.5	3.0 (2.6, 3.4)	< 0.0001
Abdominal pain	No past history	188	3.8	1
	Past history	137	8.9	2.4 (1.9, 3.0)	< 0.0001
Upper GI haemorrhage	No past history	21	0.4	1
	Past history	8	0.5	1.2 (0.5, 2.9)	0.3
Iron deficiency anaemia	No past history	13	0.3	1
	Past history	6	0.4	1.5 (0.5, 4.2)	0.2
Peptic ulcer	No past history	9	0.2	1
	Past history	8	0.5	2.9 (1.0, 8.4)	0.02

^*Past history of gastrointestinal symptoms in 12 months prior to meloxicam

^†Use of NSAID's in last 3 months prior to meloxicam

^‡Concurrent use of proton pump inhibitor, or H₂-antagonist or misoprostol.