Table 1.
Mean arterial pressure (MAP), heart rate (HR), forearm blood flow (FBF) and vein diameter at baseline and at 90 min following the start of each infusion. Values are mean ± s.e. mean.
| Intra-arterial infusion | Intravenous infusion | |||
|---|---|---|---|---|
| BQ-3020 (50 pmol min−1) | SFTX6c (5 pmol min−1) | BQ-3020 (50 pmol min−1) | SFTX6c (5 pmol min−1) | |
| MAP (mmHg) | ||||
| Basal | 93 ± 3 | 86 ± 2 | 87 ± 2 | 89 ± 2 |
| 90 min | 96 ± 5 | 92 ± 3 | 86 ± 3 | 90 ± 3 |
| HR (beats min−1) | ||||
| Basal | 56 ± 3 | 54 ± 2 | 57 ± 3 | 57 ± 3 |
| 90 min | 56 ± 2 | 54 ± 3 | 55 ± 3 | 58 ± 4 |
| FBF (ml 100 ml −1 min−1) | ||||
| Control arm | ||||
| Basal | 4.0 ± 0.8 | 4.4 ± 1.0 | ||
| 90 min | 5.0 ± 1.4 | 5.2 ± 1.0 | ||
| Infused arm | ||||
| Basal | 4.6 ± 1.0 | 3.9 ± 0.7 | ||
| 90 min | 3.6 ± 0.7 | 3.2 ± 0.1 | ||
| Vein diameter (arbitrary units) | ||||
| Basal | 2.7 ± 0.4 | 2.6 ± 0.3 | ||
| 90 min | 2.3 ± 0.3 | 1.8 ± 0.4 | ||