Table 1.

Effect of concomitant NSAID administration on plasma lithium concentrations.

NSAID	Dose (mg day−1)	Patients (number)	Mean increase in serum lithium concentration	Reference
Aspirin	4000	Volunteers (5)	2%	Reimann et al. 1983 [7]
Sulindac	300	Patients (6)	0%	Ragheb & Powell, 1986 [8]
Ibuprofen	1600	Volunteers (11)	15%	Kristoff et al. 1986 [9]
	1800	Patients (9)	34%	Ragheb, 1987 [10]
Naproxen	750	Patients (7)	16%	Ragheb &Powell, 1986 [8]
Celecoxib	400	Volunteers (24)	17%	not yet published [29]
Flurbiprofen	200	Patients (11)	19%	Hughes et al. 1997 [11]
Lornoxicam	8	Volunteers (12)	20%	Ravic et al. 1993 [14]
Ketorolac	40	Volunteers (5)	21%	Cold et al. 1998 [12]
Indomethacin	150	Volunteers (5)	24%	Reimann et al. 1983 [7]
	150	Volunteers (4)	30%	Frölich et al. 1979 [13]
	150	Patients (3)	59%	Frölich et al. 1979 [13]
Diclofenac	150	Volunteers (5)	26%	Reimann & Frölich, 1981 [6]
Tenidap	120	Volunteers	39%	Apseloff et al. 1995 [15]