Table 2.
Estimated infant dose for citalopram and demethylcitalopram (as citalopram equivalents), and infant plasma concentrations of citalopram and demethylcitalopram.
| Citalopram | Demethylcitalopram | |||||
|---|---|---|---|---|---|---|
| Volunteer | Infant dose as % of maternal dose Method A1 | Method B2 | Infant plasma concentration (µg l−1) | Method A1 | Infant dose as % of maternal dose Method B2 | Infant plasma concentration (µg l−1) |
| 1 | 3.9 | 3.6 | 2 | 1.8 | 1.7 | ND3 |
| 2 | 1.6 | 3.0 | ND | 0.6 | 1.2 | ND |
| 3 | 1.3 | 2.0 | ND | 0.6 | 0.9 | ND |
| 4 | 5.6 | 5.9 | 2.3 | 1.6 | 1.5 | 2.2 |
| 5 | 3.9 | 4.4 | 2.3 | 1.9 | 2.3 | 2.2 |
| 6 | 2.7 | 4.0 | ND | 1.0 | 1.5 | ND |
| 7 | 3.6 | 3.0 | ND | 1.0 | 0.7 | ND |
| Mean (95% CI) | 3.2 (1.9, 4.6) | 3.7 (2.6, 4.8) | 1.2 (0.7, 1.7) | 1.4 (0.9, 1.9) | ||
1
Infant dose (cumulative dose over 24 h in µg/(infant body wt in kg × 1000)/mother's dose in mg kg−1) as a percentage.
2
Infant dose (average milk concentration in µg l−1 × 0.15 l kg−1 day−1 × 1000)/mother's dose in mg kg−1) as a percentage.
3
ND = less than detection limit (1 µg l−1).