Table 2.
Pharmacokinetic parameters of PSC.
| PSC | PSC + morphine | Ratio (%) | 95% confidence interval | P value | |
|---|---|---|---|---|---|
| Cmax (ng·ml−1) | 1810 ± 461 | 1759 ± 481 | 97.2 | 86.8–108.9 | NS |
| AUC(0, last) (ng ml−1h) | 8490 ± 3479 | 8517 ± 3316 | 100.7 | 90.3–112.3 | NS |
| t1/2, (h) | 16.2 ± 9.8 | 16.9 ± 8.3 | 0.71 * | −3.03–4.45 | NS |
| AUC(0,∞) (ng ml−1 h) | 9695 ± 4314 | 9660 ± 3804 | 100.7 | 91.0–111.5 | NS |
| Vz (l) | 355 ± 141 | 373 ± 109 | 108.1 | 89.5–130.5 | NS |
| Vs s (l) | 227 ± 66.9 | 233 ± 58.3 | 103.5 | 90.2–118.9 | NS |
| CL (l h−1) | 17.5 ± 5.4 | 17.3 ± 5.0 | 99.3 | 89.7–109.9 | NS |
n = 18; data are given as mean ± s.d.
*
difference in h; P > 0.05.