Table 3.
Pharmacokinetic parameters of morphine.
| Morphine | PSC + Morphine | Ratio | 95% confidence interval | P value | |
|---|---|---|---|---|---|
| tmax (h) | − † | − † | |||
| Cmax (ng ml−1) | 18.6 ± 4.7 | 20.4 ± 3.6 | 109.9 | 93.2–127.6 | NS |
| AUC(0,last) (ng l−1 h) | 45.5 ± 10.6 | 48.6 ± 8.6 | 107.0 | 94.0–121.9 | NS |
| t½ (h) | 2.4 ± 1.7 | 2.3 ± 0.9 | −0.13 * | −1.08–0.82 | NS |
| AUC(0,∞) (ng ml−1 h) | 49.7 ± 9.2 | 52.6 ± 9.8 | 106.0 | 98.1–114.4 | NS |
| Vz (l) | 571 ± 540 | 470 ± 124 | 98.9 | 73.2–133.8 | NS |
| Vss (l) | 406 ± 372 | 305 ± 50 | 91.1 | 69.8–118.9 | NS |
| CL (l h−1) | 156 ± 28.3 | 147 ± 22.7 | 94.8 | 87.4–102.8 | NS |
n = 18; data are given as mean ± s.d.
*
difference in hours; P > 0.05
†
assumed to be time of termination of infusion.