Table 1.
Pharmacokinetics of lovastatin alone and lovastatin during diltiazem treatment.
| AUC (ng ml−1 h) | t1/2 (h) | Cmax (ng ml−1) | tmax (h) | |||||
|---|---|---|---|---|---|---|---|---|
| Volunteer | L | L + DTZ | L | L + DTZ | L | L + DTZ | L | L + DTZ |
| 1 | 48 | 110 | * | 13 | 4.3 | 24.8 | 2.5 | 2.5 |
| 2 | 58 | 102 | * | 28 | 7.2 | 13.5 | 2.5 | 2.5 |
| 3 | 42 | 58 | 12 | * | 4.3 | 3.3 | 4.0 | 12.0 |
| 4 | 29 | 29 | 27 | 37 | 1.8 | 2.8 | 4.0 | 2.0 |
| 5 | 75 | 22 | 8 | 4 | 19.6 | 3.6 | 2.5 | 3.0 |
| 6 | 47 | 61 | 9 | 39 | 6.4 | 6.3 | 2.5 | 2.5 |
| 7 | 72 | 114 | 33 | * | 4.6 | 6.8 | 0.8 | 8.0 |
| 8 | 19 | 39 | 6 | 20 | 2.4 | 3.1 | 4.0 | 6.0 |
| 9 | 129 | 144 | 9 | 20 | 15.8 | 19.6 | 3.0 | 3.0 |
| 10 | 125 | 126 | 35 | 7 | 15.2 | 8.2 | 1.5 | 6.0 |
| Mean | 64 | 81 | 17 | 21 | 8.2 | 9.2 | 2.7 | 4.8 |
| s.d. | 37.2 | 43.8 | 12.2 | 13.0 | 6.31 | 7.67 | 1.08 | 3.25 |
| C.I. | −39, 6 | −26, 5 | −8, 6 | −4, 0 | ||||
L = lovastatin L + DTZ = lovastatin during diltiazem treatment.
*
unable to estimate t1/2. C.I. = 95% confidence interval for differences.