Table 1.
Times of doses | ||||
---|---|---|---|---|
Dosage and regimen | 08.00 h | 15.30 h | 20.00 h | 23.00 h |
Group 1: 1000 µg day−1 | ||||
three times daily (µg) | 330 + P | 330 + P | P + P | 330 + P |
twice daily (µg) | 250 + 250 | P + P | 250 + 250 | P + P |
Group 2: 1500 µg day−1 | ||||
three times daily (µg) | 250 + 250 | 250 + 250 | P + P | 250 + 250 |
twice daily (µg) | 500 + 250 | P + P | 500 + 250 | P + P |
Group 3: 2500 µg day−1 | ||||
three times daily (µg) | 330 + 500 + P | 330 + 500 + P | P + P + P | 330 + 500 + P |
twice daily (µg) | 500 + 500 + 250 | P + P + P | 500 + 500 + 250 | P + P |
P = placebo.